Brucella abortus’a Karşı Yerel Bakteriyofaj İzolasyonu ve Konakçı Spesifitesinin Değerlendirilmesi

Bacteriophages are viruses that infect bacteria. Although their effects on bacteria have been known for many years, the discovery of antibiotics has limited widespread use bacteriophages against bacterial infections. However, it is now essential to reconsider using phage therapies due antimicrobial-resistant and uncontrolled zoonotic diseases becoming a global problem. This study aimed isolate lytic phages B. abortus, most common agent causes bovine brucellosis, which become worldwide animal public health performed isolation from cattle farms be previously or currently infected, also evaluates these melitensis, suis biotypes, ovis neotomae abortus field isolates in our culture collection. In this process, seven local brucella-specific were identified by evaluating 112 samples via general purification. The lyticity isolated analyzed with international reference: (bv 1, 2, 3, 4, 5, 6, 9), melitensis 3), 5) biovars, ovis, strains (n:20). It was found 85% produced lysis pattern like Tbilisi Φ through phages. terms results, three different specific (98 Φ, 104 (P35, P70, P94/1, P94/2, P94/3) phages). thought applying cocktails prepared fight brucellosis will significantly contribute controlling disease. Since 15% rough strains, recommended R/C included cocktails.